WitrynaIntermediate-dose melphalan was designed as two non-myeloablative, intravenous doses of melphalan of 70 mg/m each. This dose is lower than that reported by others35 and is based on our previous phase II trial,36 in an attempt to achieve intensive therapy without restricting the availability of autologous stem cells. WitrynaMelphalan is an alkylating drug with myeloablative and anti-tumor effect, which has been used in conditioning regimens prior to stem cell transplantation in different hematologic and non-hematologic malignancies [6-8].
Phase IV, Multicenter, Open-Label, Safety, and Efficacy Study of …
WitrynaThe BuMel myeloablative regimen following COG induction was well tolerated, with acceptable pulmonary and hepatic toxicity. Keywords: Busulfan; Melphalan; … Witryna15 paź 2008 · Allogeneic Non-Myeloablative Stem Cell Transplantation Using Fludarabine and Melphalan Conditioning Regimen for Chronic Lymphocytic Leukemia, Lymphoma, and Multiple Myeloma ... Melphalan will be administered following the completion of Fludarabine infusion at day -2. In case of unrelated donor HCT, … fma fort meade alliance
Table 6.1, [Examples of myeloablative, non-myeloablative and …
WitrynaThree of five responders had received prior myeloablative doses of melphalan. We hypothesized that BSO given with melphalan doses greater than 15 mg/m 2 would enhance activity against neuroblastoma and be tolerable by adding hematopoietic stem cell support to abrogate myelotoxicity, and prohibition of concomitant cephalosporins … Witryna8 sty 2024 · As a palliative treatment, it helps control myeloma cell propagation. Melphalan also is used at higher doses as myeloablative chemotherapy prior to … Witryna28 sie 2015 · Autologous stem cell transplantation (ASCT) after high-dose melphalan conditioning is considered a standard of care procedure for patients with multiple myeloma (MM). Current formulations of melphalan (eg, Alkeran for Injection [melphalan hydrochloride]; GlaxoSmithKline, Research Triangle Park, NC, USA) have marginal … fmb286