Gb004
WebKnow about technical details of GB004 like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com. Technical details about GB004, learn more about the structure, uses, toxicity, action, side … WebMay 1, 2024 · GB004 is an orally administered, small molecule, gut-targeted stabiliser of hypoxia-inducible factor-1α, a transcription factor with protective roles at the epithelial layer of the inflamed gut ...
Gb004
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WebGB004 is an orally administered, small molecule, gut-targeted stabiliser of hypoxia-inducible factor-1α, a transcription factor with protective roles at the epithelial layer of the inflamed … WebJan 15, 2024 · GB004 was selected based on its gut-targeted profile to limit systemic on-target effects associated with HIF-α stabilisation. GB004 is in clinical development for the …
WebOct 12, 2024 · GB004 is an oral, gut-targeted HIF-1α stabilizer, designed to promote mucosal healing and resolve local inflammation through a non-immunosuppressive mechanism of action in patients with... WebFigure 1. GB004 mechanism of action OBJECTIVE • HIF-1α stabilization by GB004 drives expression of genes that promote barrier restitution and downmodulate inflammation in animal models. To investigate further, we assessed the direct effects of GB004 on barrier integrity using a human differentiated monolayer assay. We also
WebFeb 4, 2024 · Gossamer Bio to Host Webcast Focused on its Inflammatory Bowel Disease Program, GB004, on February 18, 2024. February 04, 2024 07:05 AM Eastern Standard Time. WebJan 23, 2024 · GB004 is a small molecule prolyl hydroxylase inhibitor (PHDi) that stabilizes hypoxia inducible factors (HIF1-α), key transcription factors involved in the protective cellular responses at the intersection of hypoxia and inflammation. GB004 was selected based on its gut-targeted profile to limit systemic on-target effects associated with HIF1 ...
WebGB004 is a small molecule prolyl hydroxylase inhibitor (PHDi) that stabilizes hypoxia inducible factors (HIF1-α), key transcription factors involved in the protective cellular …
WebGB004, a Novel Gut-Targeted Prolyl Hydroxylase Inhibitor for Inflammatory Bowel Disease: First In-Human Multiple Dose Study in Healthy Subjects With Gut Biopsies newest natchitoches hotel roomsWebJun 25, 2024 · AKB-4924 (to be known as GB004) is an investigational hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilizer in development for IBD. Unlike other HIF stabilizers in clinical development, which stabilize HIF-2 and stimulate erythropoiesis, GB004 preferentially stabilizes HIF-1 alpha, and has profound anti-inflammatory and mucosal … newest navy ships 2021newest nba 2k22 locker codesWebJul 7, 2024 · Digital Oral Presentation Title: Target Engagement and Pharmacodynamic Biomarker Analysis following Treatment with the Oral Gut-Targeted HIF-1α Stabilizer … newest navy shipWebGB004: Oral HIF-1α Stabilizer for Inflammatory Bowel Disease (IBD) Primary endpoint week 12 topline data from the Phase 2 SHIFT-UC study in patients with mild-to-moderate ulcerative colitis (UC) are expected in the second quarter of 2024. newest navy seal bookWebMar 31, 2024 · - Seralutinib and GB004 continue to progress through ongoing Phase 2 TORREY and SHIFT-UC clinical trials for Pulmonary Arterial Hypertension and Ulcerative Colitis , respectively - ... April 11, 2024 newest nba franchiseWebOct 31, 2024 · GB004 was licensed from Aerpio Pharmaceuticals in 2024. In addition to $35 million covering two upfront payments, Gossamer is potentially obligated to pay out approval and sales milestones ... newest naval ships