WebSep 10, 2004 · The association of galectin-3 ablation with enhanced susceptibility to AGE-induced renal disease, increased AGE levels and signaling, and altered AGE-receptor … WebJun 6, 2015 · Galectin-3 knockout mice (KO) and wild-type mice (WT) were fed either a high-fat diet (HFD) (60 % fat calories) to produce insulin resistant diabetes, or standard chow (12 % fat calories), and their metabolic and endothelial responses were measured. After 8 weeks, the aortic and skeletal muscle endothelia were isolated by fluorescence …

Mice lacking galectin-3 (Lgals3) function have decreased …

WebApr 27, 2024 · Gal-3 overexpression strongly promoted Aβ oligomerization in C57Bl/6 WT mice injected intrahippocampally with Aβ, whereas Aβ oligomerization was reduced in Gal-3-knockout C57Bl/6 mice . Moreover, there was an age-dependent increase in Gal-3 expression and endogenous Aβ oligomerization when evaluating the APP/PS1 … WebMay 1, 2016 · Galectin-3 expression peaks in the inflammatory phase and remains present into the proliferative phase, primarily expressed in arginase I-positive cells. 6-mm, full-thickness skin wounds were inflicted into the backs … ehba doosje

Sciatic nerve regeneration is accelerated in galectin-3 knockout mice ...

WebMay 1, 2009 · The main result of this study is that the galectin-3 knockout mice exhibited a much faster regeneration of sciatic nerve fibers after surgical compression, compared to wild-type animals subjected to the same trauma. These results were observed and confirmed by light microscopy, and quantification of axon area, fiber area, myelin sheath … WebMay 1, 2009 · Galectin-3 knockout mice showed earlier functional recovery and faster regeneration than the wild-type animals. We concluded that the absence of galectin-3 allowed faster regeneration, which may be associated with increased growth of Schwann cells and expression of β-catenin. This would favor neuron survival, followed by faster … WebNov 1, 2001 · Galectin‐3 knockout mice obtained by gene ablation and the corresponding wild‐type mice were rendered diabetic with streptozotocin and killed 4 months later, together with age‐matched nondiabetic controls. Despite a comparable degree of metabolic derangement, galectin‐3‐deficient mice developed ac‐celerated glomerulopathy vs. the ... ehbads.hrsa.gov