Chlorpromazine seizure threshold
WebOf the first-generation antipsychotic medications, chlorpromazine appears to be associated with the greatest risk of seizure provocation, although other first-generation antipsychotics also lower seizure threshold. ... Olanzapine can lower seizure threshold and induce epileptiform discharges. However in patients on olanzapine for the treatment ... WebFeb 1, 2001 · people with epilepsy should be aware of the possibility that medicines may lower their seizure threshold medications which may alter the seizure threshold …
Chlorpromazine seizure threshold
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WebDec 23, 2024 · To treat nausea and vomiting, chlorpromazine dose can range from 10 to 25 mg orally every 4 to 6 hours as needed. If used as an intramuscular or intravenous injection, the dose can range from 25 to 50 mg every 4 to 6 hours as needed. Persistent singultus can be treated by giving 25 to 50 mg of chlorpromazine orally every 6 to 8 hours. WebChlorpromazine lowers the seizure threshold (a dose-related effect) so convulsions may occur in patients not previously known to be epileptic. Individual response to chlorpromazine overdose is variable - an ingestion of 20 g has been survived, whilst 2 g has proved fatal.
WebNov 21, 2012 · In large investigations, seizure incidence rates have been reported to range from ∼0.1 to ∼1.5% in patients treated with therapeutic doses of most commonly used antidepressants and antipsychotics (incidence of the first unprovoked seizure in the general population is 0.07 to 0.09%). WebSeizure has been estimated to occur in association with clozapine use at a cumulative incidence at one year of approximately 5%, based on the occurrence of one or more seizures in 61 of 1743 patients exposed to clozapine during its clinical testing prior to domestic marketing (i.e., a crude rate of 3.5%). The risk of seizure is dose-related.
WebSeizure has been estimated to occur in association with clozapine use at a cumulative incidence at one year of approximately 5%, based on the occurrence of one or more seizures in 61 of 1743 patients exposed to clozapine during its clinical testing prior to domestic marketing (i.e., a crude rate of 3.5%). The risk of seizure is dose-related. WebConcurrent use of chlorpromazine with methoxsalen, trixsalen, or tetracycline can potentiate intraocular photochemical damage. Concurrent use of metrizamide can lower the seizure threshold. Concurrent use of chlorpromazine with medications known to alter hepatic microsomal enzyme activity may result in increased hepatotoxicity.
WebOct 1, 2024 · Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary. Potentiation of anticonvulsant effects does not occur. However, it has been reported that chlorpromazine may interfere with the metabolism of phenytoin and thus precipitate phenytoin toxicity.
WebOct 13, 2024 · - Epileptics, since chlorpromazine may lower the seizure threshold. Treatment must be discontinued if seizures occur. - Elderly patients presenting with heightened susceptibility to orthostatic hypotension, sedation and extrapyramidal effects; chronic constipation (risk of paralytic ileus), and potentially prostatic hypertrophy. kill fishe songWebNov 9, 2024 · For first-generation antipsychotics such a risk appears to be relatively low, with the exception of chlorpromazine. Among second-generation antipsychotics, … kill for the job 意味WebSerious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, severe lowering of the seizure threshold, … kill for nothing fight for myselfWebThis medication should be used with caution in patients at risk for seizures, as it lowers the seizure threshold. Chlorpromazine has a low risk of (early) extrapyramidal reactions, … killgraphicengine.exekilley\\u0027s mandibular fracture book pdfWeba low seizure threshold myasthenia gravis, a skeletal muscle disorder glaucoma, an increased pressure in the eye a heart attack angina, a type of chest pain a low supply of oxygen rich blood to... killgrave dc comicsWebMar 19, 2014 · Among the first generation antipsychotics, chlorpromazine appears to be the one most associated with the greatest risk of seizures, whereas in the newer … killguss consulting