WebApr 3, 2024 · At the same time, genome-wide association studies (GWAS) have identified numerous common variants associated with brain structure. In this study, we integrate these findings, aiming to identify proteins, metabolites, or microbes that have a putative causal association with subcortical brain structure volumes via a two-sample Mendelian ... WebDec 7, 2024 · Utilizing a two-stage proteome-wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain …
Integrative Analysis of Proteome-wide Association Studies an ...
WebApr 22, 2024 · To that end, we integrated human brain proteomes with PTSD GWAS results to perform a proteome-wide association study (PWAS) of PTSD, followed by Mendelian randomization, using a discovery and confirmatory study design. Brain proteomes (N = 525) were profiled from the dorsolateral prefrontal cortex using mass spectrometry. WebDec 6, 2024 · tudies, we first conducted a proteome-wide association study of alcohol dependence by integrating alcohol dependence genome-wide association studies with 2 human brain reference proteomes of dorsolateral prefrontal cortex from the Religious Order Study and Rush Memory and Aging Project and the Banner Sun Health Research … jean davaud
The Genetic Architecture of Sleep Health Scores in the UK NSS
WebApr 10, 2024 · The authors carried out a two-stage proteome-wide association study (PWAS) combining brain proteome data with MS-linked genome-wide association study (GWAS) data from over 40,000 people. They first identified 51 genes where protein abundance was linked to MS risk, which was narrowed down to 18 in a confirmatory PWAS. WebDec 1, 2024 · In this study, we performed proteome-wide association studies ... In addition, Wingo et al. also conducted a validation study using the brain proteome from … WebApr 4, 2024 · Genetic control of body weight by the human brain proteome. Highlights. 25 genome-wide hits for body mass index (BMI) were mapped to brain proteins; 35 additional brain proteins were linked to BMI using Mendelian randomization; ... Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated … la bella salumeria menu