Bivalirudin thrombin time
Web摘要： The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and 0.75 mg/kg … WebJun 13, 2005 · Angiomax. Generic Name. Bivalirudin. DrugBank Accession Number. DB00006. Background. Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered …
Bivalirudin thrombin time
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WebAdditionally, bivalirudin inhibits thrombin-induced platelet activation whereas heparin activates platelets. Greater platelet adhesion to the stent surface in patients treated with heparin within the first 24 h could explain the increased risk of stent thrombosis after this time when the antithrombotic effects of the anticoagulants are no ... WebSep 18, 2024 · We use the plasma-diluted thrombin time to measure the direct thrombin inhibitors [DTIs] dabigatran, argatroban, or bivalirudin. The assay is similar to the …
WebJan 4, 2012 · As previously demonstrated, the plasma-diluted thrombin time assay is useful for monitoring intravenous DTIs such as bivalirudin and argatroban. 1 The dose … WebDirect thrombin inhibitors, including argatroban and bivalirudin, can increase the clot formation time, but may have only a minor effect on the maximum clot strength. 18 The use of an ecarin clotting time, currently …
WebResults: Bivalirudin is a synthetic polypeptide that directly inhibits thrombin by binding simultaneously to its active catalytic site and its substrate recognition site. After … WebJan 5, 2014 · Dose-response relationship between bivalirudin added to normal pooled plasma and the ecarin chromogenic assay (ECA) (A), activated partial thromboplastin …
WebMay 13, 2024 · Similar to thrombin time (TT), normal reptilase time excludes abnormalities in the fibrin formation process of the coagulation cascade; however, the test is not sensitive to heparin (low-molecular-weight heparin or unfractionated heparin) or direct antithrombin inhibitors (eg, hirudin, bivalirudin, argatroban, dabigatran).
WebJul 26, 2005 · The activated clotting time (ACT) (Figure 2D) is a point-of-care whole-blood clotting test used to monitor high-dose heparin therapy or treatment with bivalirudin. 10 The dose of heparin or bivalirudin required in these settings is beyond the range that can be measured with the aPTT. 16 Typically, whole blood is collected into a tube or ... brühl sofa stoffeWebBivalirudin (Hirulog, Angiomax) is a specific, reversible and direct thrombin inhibitor with a predictable anticoagulant effect. It is cleared by both proteolytic cleavage and renal … brühl sofa alba all in oneWebSep 16, 2013 · Subsequent to introduction of bivalirudin, a direct thrombin inhibitor that was shown to be safer than heparin plus GP IIb/IIIa inhibitors for PCI, the planned usage of GP IIb/IIIa inhibitors declined because of concern about increased bleeding complications. ... If bivalirudin is being used at the time of PCI and at least 300 mg of clopidogrel ... bruhl sports directWebFor bivalirudin, other tests have emerged such as dilute thrombin time (dTT) and ecarin chromogenic assay (ECA); however, their utilities in pediatrics are unexplored. … bruhl trousers amman jordanWebWe compared the plasma diluted thrombin time (1:4 dilution of patient plasma with normal plasma) and the aPTT in patient samples spiked with argatroban, bivalirudin, or … bruhl traductionWebArgatroban and bivalirudin are parenteral direct inhibitors of the activity of thrombin, but, unlike heparin, can inhibit both soluble as well as clot-bound thrombin. ... Other coagulation assays such as the dilute thrombin time (dTT), chromogenic anti-IIa assays, and the ecarin clotting time (ECT) can be used. The intensity of anticoagulation ... ewok teams backgroundhttp://clsjournal.ascls.org/content/ascls/26/1/54.full.pdf ewok theme